- Title
- Prevalence of colonic neoplasia and advanced lesions in the normal population: a prospective population-based colonoscopy study
- Creator
- Forsberg , Anna M.; Kjellstrom , Lars; Agreus, Lars; Andreasson , Anna Nixon; Nyhlin , Henry; Talley, Nicholas J.; Bjorck, Erik
- Relation
- Scandinavian Journal of Gastroenterology Vol. 47, Issue 2, p. 184-190
- Publisher Link
- http://dx.doi.org/10.3109/00365521.2011.647062
- Publisher
- Informa Healthcare
- Resource Type
- journal article
- Date
- 2012
- Description
- Objective: There are few prospective studies of the prevalence of colonic neoplasia in the normal population. In order to properly evaluate screening-protocols for colorectal cancer in risk groups (e.g., older subjects or those with a family history), it is essential to know the prevalence of adenomas and cancer in the normal population. Methods: A prospective population-based colonoscopy study on 745 individuals born in Sweden aged 19–70 years was conducted (mean age 51.1 years). All polyps seen were retrieved and examined. Results: Out of the 745 individuals 27% had polyps, regardless of kind. Adenomas were found in 10% of the individuals and finding of adenomas was positively correlated to higher age. Men had adenomas in 15% and women in 6% of the cases. Women had a right-sided dominance of adenomas. Hyperplastic polyps were seen in 21% of the individuals. The presence of hyperplastic polyps was significantly positively correlated to the presence of adenomas. Advanced adenomas were seen in 2.8% of the study participants, but no cancers were detected. Conclusion: One in 10 healthy subjects had an adenoma but advanced adenomas were uncommon. Men and women have a different adenoma prevalence and localization. The results provide baseline European data for evaluating colonoscopy screening-protocols for colorectal cancer risk groups, and the findings may have implications for colon cancer screening in the normal, otherwise-healthy population.
- Subject
- adenoma; colonoscopy; population-based; prospective
- Identifier
- http://hdl.handle.net/1959.13/939310
- Identifier
- uon:12776
- Identifier
- ISSN:0036-5521
- Language
- eng
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